Why Humalog® KwikPen U-100?
Humalog is a fast-acting insulin that is used to control blood glucose levels, specifically blood sugar spikes that may happen naturally with meals.
It is different than long-acting insulin which are used to manage insulin levels through the day.
Humalog is now available through the Humalog U-100 KwikPen that is easy to use and portable. You can take it anywhere since it doesn’t have to be refrigerated after first use.
HUMALOG KwikPen® insulin lispro injection 100 units/mL, 3 mL single-patient-use pen
Humalog KwikPen is an insulin pen that contains insulin lispro which is used to treat diabetes.
This rapid-acting insulin works quicker than human insulin in the body as the insulin molecule has been changed slightly.
Humalog is to substitute for the lack of insulin created by the pancreas and works effectively to manage blood sugar levels.
It works very quickly and its duration is shorter than soluble insulin (2 to 5 hours).
Each Humalog KwikPen delivers 1–60 units in increments of 1 unit.
This disposable single-patient-use prefilled insulin pens contains a total of 300 units of Humalog.
Users can administer multiple doses. The dial allows you to give yourself from 1 to 60 units of insulin from a single injection. Each turn of the knob will click and delivers a single unit.
Each dosage is displayed in a window by movement of a dial. The dial moves slightly after using the pen which may sometimes go unnoticed. It will reach the end of the cartridge when all 300 units have been used.
Before using Humalog KwikPen be sure to read all information from your leaflet carefully and follow instructions as provided by your doctor or pharmacist.
Your doctor may advise using Humalog KwikPen along with longer-lasting insulin.
Getting started on Humalog
When getting started with using a Humalog KwikPen you should note the following:
- Take it within 15 minutes before or immediately after meals
- Hypoglycemia (low blood sugar) is a potential side effect that can lead to seizures or even death. Be aware of possible symptoms such as increased heartbeat, slurred speech, confusion, sweating, dizziness or light-headedness, headache, shakiness, blurred vision, anxiety, mood changes, irritability or hunger.
- Treat low blood sugar by carrying a sugary snack such as candy or a sugary drink with you to put you back into a safe range.
- Understand the units of measurement on the device to ensure you are taking the correct dosage with your meals as recommended by a doctor
Humalog Kwikpens are small, portable, lightweight prefilled insulin pens that can be taken with meals. It makes taking your insulin dosage easily and discreetly when away from home.
Humalog KwikPen: Usage
The medication you are provided should only be used by you. Do not share this pen with others as they may have adverse reactions even if they have a similar condition. This is also to limit the transmission of diseases.
Only use this medication as directed by your doctor and discuss any concerns if you are unsure about how to use it.
You should normally administer the Humalog KwikPen within 15 minutes of a meal or soon afte starting your meal. Your doctor should provide instructions on dosage, when to take and frequency. Be sure to follow instructions as advised.
It should only be administered subcutaneously (under the skin). If you are injecting in any other way, be sure to advise your physician or nurse.
Since Humalog is already dissolved in water, you don’t need to mix it. Inspect before use if to ensure insulin is colorless, clear and does not contain any particles in it.
Before administering Humalog KwikPens:
-Wash your hands thoroughly
-Read any instructions if needed and follow instructions that come with the medication or as instructed by your doctor
-Use a clean needle (needles are not included)
-Prime KwikPen before use to ensure insulin comes out and clear of any air bubbles left in the pen. While small air bubbles are harmless, larger air bubbles can affect your insulin dose
- Clean your skin before injecting Humalog
- Do not inject into a vein
- After an injection leave the needle in the skin for at least 5 seconds to ensure you have taken the entire dose
- Do not rub the injection site
- Inject at least half an inch (1 cm) from the last injection site
- Whether you inject in the thigh, buttock, abdomen or upper arm, your Humalog injection will work faster than soluble human insulin
- Do not administer Humalog intravenously. This should only be done by a doctor under extreme circumstances
- Only administer medication as advised by your physician or nurse
After injecting Humalog
After you have administered the injection, unscrew the needle from the KwikPen using the outer needle cap. This keeps the insulin from leaking, ensures it’s sterile and that it stops air from entering the pen and needle from clogging.
Using Humalog with an infusion pump
Humalog KwikPen insulin should only be used under the skin. Do not attempt to administer your insulin any other way. Take as directed and based on the type of Humalog you have been prescribed.
If you have taken more insulin than needed or unsure about the amount you have administered, check your blood sugar levels as you may experience low blood sugar.
Carry glucose tablets, candy or sugary drinks with you in the event you experience hypoglycemia.
If your skin gets pale or your breathing becomes shallow, advise a medical expert immediately.
Glucagon injections may be recommended to treat hypoglycemia if experienced frequently.
If you are taking less than prescribed then you may experience high blood sugar.
Not not change your insulin unless under the direction of your doctor. Speak to your doctor or pharmacist if you have any further questions about this medication.
Humalog KwikPen: Contents & Storage
The active incredient in Humalog KwikPens are a substance called insulin lispro which is made in a laboratory using a recombinant DNA technology process. Insulin lispro is closely related to human insulin that is secreted by the pancreas.
Other ingredients are m-cresol, zinc oxide, dibasic sodium phosphate 7 H2O, glycerol and water for injection. Hydrochloric acid or sodium hydroxide may have been used to adjust the acidity.
Contents of your Humalog KwikPen pack
Humalog 100 units/ml KwikPen solution for injection is a sterile, clear, colourless, aqueous solution and contains 100 units of insulin lispro in each millilitre (100 units/ml) solution for injection. Each Humalog KwikPen contains 300 units (3 millilitres).
The Humalog KwikPen comes in a pack of 5 pre-filled pens or a multi-pack of 2 x 5 pre-filled pens. Not all pack sizes may be marketed. The Humalog 100 units/ml in your pre-filled pen is the same as the Humalog 100 units/ml, which comes in separate Humalog 100 units/ml cartridges. The KwikPen simply has a built in cartridge. When the pre-filled pen is empty you cannot use it again.
Before use, you should store Humalog KwikPen in a refrigerator between 2°C – 8°C)
Keep Humalog KwikPen at room temperature (below 30°C) and discard after 28 days or use after the expiry date that should be available on the label and carton.
Do not freeze insulin or store near heat as this can degrade medication.
Keep away from children and do not store with needle attached.
Do not use this medication if it isn’t clear, colorless and contains any floating particles. Inspect each time before application.
Do not dispose medication via household waste or wastewater. Speak to your pharmacist about how to properly dispose of Humalog KwikPen. These measure are in place to protect the environment.
Humalog KwikPen: Warnings & Precautions
Do NOT use Humalog KwikPen
- If you have low blood sugar (hypoglycemia)
- If you are allergic to insulin lispro or other ingredients part of the formulation
Before use, check the label to ensure it’s the correct pre-filled pen (Humalog KwikPen); correct brand and type as prescribed and provided by your pharmacist.
Keep close watch of blood sugar levels using a blood glucose testing kit to ensure insulin therapy is working and that you are not experiencing any symptoms. Consider scheduling your meals carefully in addition to how often and how rigorous you plan on exercising.
Some have experienced hypoglycemia when switching from animal insulin to human insulin. Some warning signs may be less obvious, discuss with your doctor if you have issues determining symptoms such as hypoglycemia.
Advise your doctor or pharmacist if you have experienced any of the following:
- Have become recently ill
- Experiencing trouble with liver or kidneys
- Have increased the frequency of exercise
- Are planning on travelling to other countries as this may change your insulin schedule due to time zone changes
- If you are experiencing heart failure or unusual shortness of breath notify your doctor
- Have experienced sudden weight gain or localized swelling (oedema)
- Your insulin you require may change if you have consumed alcohol.
This pen is not recommended to be used by the visually impaired or blind without proper training.
When using Humalog KwikPens, you should rotate injection sites in order to avoid any skin changes such as lumps under the skin. By injecting into lumpy areas, insulin may not work as effective. If you find yourself injecting into a lumpy area, you should advise your doctor who may tell you to closely monitor your blood glucose levels, and adjust the regimen of other medication currently being taken.
Your insulin may need to be adjusted if you are taking any of the following medications along with Humalog KwikPens:
- oral hypoglycemic
- acetyl salicylic acid
- sulpha antibiotics
- thyroid hormone replacement therapy
- beta blockers or stimulants (such as salbutamol, terbutaline, ritodrine etc)
- some agiotensin converting enzyme (ACE) inhibitors such as captopril, enalapril and agiotensin II receptor blockers
Notify your doctor of any other medication, vitamins & supplements including over the counter medication.
If you are pregnant or breastfeeding, dosage amounts may be modified, especially during the first 3 months. If you are currently breast-feeding you may also need to modify your insulin intake and diet.
Due to hypoglycemia, your ability to focus may be affected. Consider this when operating any heavy machinery or driving. Speak to your doctor about whether you are safe to operate a vehicle when using this diabetes medication.
This medicine contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially ‘sodium-free’.
Humalog KwikPen: Side Effects
As with any insulin medication, you may experience side effects, however not everyone experiences them.
Symptoms may include:
- allergic reactions
- rash all over the body
- wheezing/difficulty breathing
- increased heart beat
- drop in blood pressure
If you experience these side effects and concerned, speak to your doctor at once.
Local allergic reactions may be experienced at injection sites that include redness, itching and swelling. This usually clears up within a few days. Notify your doctor if you are experiencing this happens to you.
However uncommon, lipodystrophy is experienced if you are injecting repeatedly to the same site. The skin may either thicken (lipohypertrophy) or shrink (lipoatrophy). Lumps under the skin may develop due to a protein called amyloid or cutaneous amyloidosis. Injecting into a lumpy area may prevent the insulin from working well. It is recommended to alternate injection sites in order to prevent any skin changes.
Oedema (swelling of the arms, ankles; fluid retention) may be experienced at the beginning of starting insulin treatment or with modifications to therapy.
If you experience any of the side effects listed above, or side effects not listed with the Humalog KwikPen, be sure to consult your physician.
Common problems with diabetes
Hypoglycemia or low blood sugar is commonly experienced by diabetics when there isn’t enough sugar in the blood and be caused if:
- You miss or delay your meals
- you apply too much insulin
- you exercise too rigorously before or after a meal
- you have an illness or infection
- you require a change in dosage amount
- you have issues with your liver or kidneys
- you have consumed a lot of alcohol
Signs of low blood sugar usually include:
- shakiness or nervousness
- feeling sick
- cold sweats
- increased heartbeat
Hyperglycemia and diabetic ketoacidosis
Hyperglycemia is experienced with there is too much sugar in the blood and your body is low on insulin. This can be caused by:
- not taking enough insulin
- taking less than the recommended dosage
- eating more than your diet suggests
- are experiencing fever, infection or stress
Hyperglyecemia can lead to diabetic ketoacidosis which is a very serious condition which can come on slowly over days. Symptoms include:
- flushed face
- decreased appetite
- feeling sick
- fruity smell on breath
- feeling tired
- increased thirst
- increased heart rate
- shortness of breath
If you are feeling ill, you may need to modify your insulin dosage. Even if you are eating less, you still need to take your insulin medication. Speak to you doctor and test your urine and blood for any symptoms as advised by your doctor.
If you feel you are experiencing severe symptoms, get medical attention immediately.